The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.
The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161.
|Name||APC Anti-Human CD161 (HP-3G10)|
|Technical Data Sheet||Download TDS|
|Alternative Names||NKR-P1A, NKRP1A|
|Isotype||Mouse IgG1, kappa|
|Cross Reactivity||Chimpanzee, Baboon, Rhesus|
Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi J-I, Oyamada A, Fujimura K, Iwamoto Y, and Yoshikai Y. 2011. J. Rheumatol. 38: 1569-1575. (Flow cytometry)
Fogal B, Yi T, Wang C, Rao DA, Lebastchi A, Kulkarni S, Tellides G, and Pober JS. 2011. J. Immunol. 187: 6268-6280. (in vitro depletion)
Pozo, D, Vales-Gomez, Mavaddat N, Williamson SC, Chisholm SE, and Reyburn H. 2006. J. Immunol. 176: 2397-2406. (Western blot)
Exley M, Porcelli S, Furman M, Garcia J, and Balk S. 1998. J. Exp. Med. 188: 867-876. (in vitro blocking, Western blot)