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Recombinant Human TNF-beta (LT-alpha) (Carrier-free)

Sizes available: 5 µg, 20 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7071
Recombinant Human TNF-beta (LT-alpha) (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human TNF-beta (LT-alpha) (Carrier-free) ..... Cat.No. 21-7071-U005 ..... Size 5 µg
$115.00
Recombinant Human TNF-beta (LT-alpha) (Carrier-free) ..... Cat.No. 21-7071-U020 ..... Size 20 µg
$179.00
Recombinant Human TNF-beta (LT-alpha) (Carrier-free) ….. Cat.No. 21-7071-U100 ….. Size 100 µg
$585.00
Recombinant Human TNF-beta (LT-alpha) (Carrier-free) ..... Cat.No. 21-7071-U500 ..... Size 500 µg
$1,610.00

Description

Details

TNF-beta, also known as Lymphotoxin alpha (LT-a), is a member of the Tumor Necrosis Factor (TNF) superfamily. It binds the same cell surface receptors, TNF RI and TNF RII, as TNF-alpha. TNF-beta is produced by activated T and B lymphocytes and has similar, but not identical, activities to TNF-α. TNF-beta has cytotoxic effects on tumor cells and also involved in regulation and mediation of inflammation, immune function, cell proliferation and differentiation, apoptosis and neurotransmission. It has also been reported to play a role in autoimmune disease.

Additional Info

Additional Info

Name Recombinant Human TNF-beta (LT-alpha) (Carrier-free)
Cat. No. 21-7071
Technical Data Sheet Download TDS
Alternative Names Tumor Necrosis Factor-beta, TNFSF1, Lymphotoxin-alpha (LT-alpha)
Amino Acid Sequence MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin-D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human TNF-beta is a secreted 172 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Apoptosis; Immune System; Inflammation​; Lipid Metabolism; Neurobiology; Proliferation; Stem Cells & Differentiation; TNF Superfamily; Allergy
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.