Toll-Free Customer Service (855) 848-6626 | 6:00 a.m.-5:00 p.m. PT

Free Shipping on Orders Over $500 View Details

Your valued source for Immunology Tools

Recombinant Human HVEM-Fc (Carrier-free)

Sizes available: 20 µg, 100 µg, 200 µg, 500 µg
Applications: Bioassay
SKU: 21-7063
Recombinant Human HVEM-Fc (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human HVEM-Fc (Carrier-free) ..... Cat.No. 21-7063-U020 ..... Size 20 µg
$76.00
Recombinant Human HVEM-Fc (Carrier-free) ..... Cat.No. 21-7063-U100 ..... Size 100 µg
$175.00
Recombinant Human HVEM-Fc (Carrier-free) ….. Cat.No. 21-7063-U200 ….. Size 200 µg
$310.00
Recombinant Human HVEM-Fc (Carrier-free) ..... Cat.No. 21-7063-U500 ..... Size 500 µg
$649.00

Description

Details

Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14 or CD270, is a member of the tumor necrosis factor (TNF) receptor family. The protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune responses. It is expressed in a variety of cell and tissue types including spleen, thymus, lung, macrophages, and T-cells. Studies suggest that HVEM plays a various regulatory roles in the mucosal immune system. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D. LIGHT (TNFSF14) and TNF-beta (TNFSF1, lymphotoxin-alpha) function as the cellular ligands for HVEM.

Additional Info

Additional Info

Name Recombinant Human HVEM-Fc (Carrier-free)
Cat. No. 21-7063
Technical Data Sheet Download TDS
Alternative Names HVEM, TNFSFR14, ATAR, TR2, CD270 antigen
Amino Acid Sequence LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VV
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to neutralize 0.25 ng/ml of hTNF-beta; induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9 µg/ml of HVEM-Fc.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. The protein has a predicted
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source Hi-5 Insect cells
Reactivity Human
Research Areas Apoptosis; Receptors; TNF Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Need Another Format? Inquire Here

Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHCF = Immunohistochemistry, Frozen Tissue; IHCP = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.