Toll-Free Customer Service (855) 848-6626 Hours 6AM-5PM PST

FREE Shipping on orders over $300*

Your valued source for Immunology Tools

Recombinant Human GDF-3 (Carrier-free)

Sizes available: 5 µg, 20 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7059
Recombinant Human GDF-3 (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human GDF-3 (Carrier-free) ..... Cat.No. 21-7059-U005 ..... Size 5 µg
$76.00
Recombinant Human GDF-3 (Carrier-free) ..... Cat.No. 21-7059-U020 ..... Size 20 µg
$199.00
Recombinant Human GDF-3 (Carrier-free) ….. Cat.No. 21-7059-U100 ….. Size 100 µg
$769.00
Recombinant Human GDF-3 (Carrier-free) ..... Cat.No. 21-7059-U500 ..... Size 500 µg
$2,295.00

Description

Details

GDF-3 is a member of the BMP family of TGF-beta superfamily proteins, and is highly homologous to GDF-9. The GDF (Growth/Differentiation Factor) group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein. With the exception of GDF-3 and -9, GDF dimers are disulfide-linked proteins. GDF-3 is a secreted protein and is expressed in undifferentiated embryonic stem (ES) cells, ossifying bone, brain, bone marrow, spleen, thymus, and adipose tissue. This protein displays inhibitory activity towards other TGF-beta superfamily members including BMPs, and participates in regulatory functions in embryogenesis. GDF­3 has been shown to be induced by a high fat diet, and is associated with adipogenesis and obesity.

Additional Info

Additional Info

Name Recombinant Human GDF-3 (Carrier-free)
Cat. No. 21-7059
Technical Data Sheet Download TDS
Alternative Names Growth/Differentiation Factor-3, Vg-related gene 2 (VGR-2)
Amino Acid Sequence AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Diabetes / Weight Regulation; Stem Cells & Differentiation; TGF-beta Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
Need Another Format? Inquire Here

Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.