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Recombinant Human 4-1BB Ligand (Carrier-free)

Sizes available: 5 µg, 20 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7135
Recombinant Human 4-1BB Ligand (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human 4-1BB Ligand (Carrier-free) ..... Cat.No. 21-7135-U005 ..... Size 5 µg
$76.00
Recombinant Human 4-1BB Ligand (Carrier-free) ..... Cat.No. 21-7135-U020 ..... Size 20 µg
$190.00
Recombinant Human 4-1BB Ligand (Carrier-free) ..... Cat.No. 21-7135-U100 ..... Size 100 µg
$555.00
Recombinant Human 4-1BB Ligand (Carrier-free) ..... Cat.No. 21-7135-U500 ..... Size 500 µg
$1,750.00

Description

Details

4-1BB Ligand, also known as TNFSF9, is a type II surface glycoprotein expressed on activated T-cells and antigen presenting cells (APCs). As a member of the TNF superfamily, it functions in promoting CD4+ and CD8+ T cell cytokine production. 4-1BB/4-1BBL signaling also enhances cell proliferation and T cell effector function. A recent study shows that 4-1BBL expressed on T cells can restrict effector T cell development under tolerogenic conditions.

Additional Info

Additional Info

Name Recombinant Human 4-1BB Ligand (Carrier-free)
Cat. No. 21-7135
Technical Data Sheet Download TDS
Alternative Names CD137L, TNFSF9, 4-1BBL, tumor necrosis factor ligand superfamily member 9
Amino Acid Sequence MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 of 5-10 ng/ml is determined by measuring dose-dependent stimulation of human IL-8 in PBMC. Results may vary due to differences between PBMC donors.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human 4-1BB Ligand consists of 185 amino acids resulting in a 19.5 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas TNF Superfamily, Apoptosis, Angiogenesis & Cardiovascular, Immune System, Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
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Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHCF = Immunohistochemistry, Frozen Tissue; IHCP = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.