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Recombinant Human MMP-3 (Carrier-free)

Sizes available: 2 µg, 10 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7073
Recombinant Human MMP-3 (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human MMP-3 (Carrier-free) ..... Cat.No. 21-7073-U002 ..... Size 2 µg
$69.00
Recombinant Human MMP-3 (Carrier-free) ..... Cat.No. 21-7073-U010 ..... Size 10 µg
$179.00
Recombinant Human MMP-3 (Carrier-free) ….. Cat.No. 21-7073-U100 ….. Size 100 µg
$955.00
Recombinant Human MMP-3 (Carrier-free) ..... Cat.No. 21-7073-U500 ..... Size 500 µg
$2,860.00

Description

Details

Matrix Metalloproteinase-3 (MMP-3) belongs to the matrix metalloproteinase family of endoproteases that function in the breakdown of extracellular matrix (ECM) in various normal and disease processes. MMP-3 targets fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. MMP­3 has been shown to be associated with fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells, and macrophages. MMP expression and activity are tightly regulated, both through the need to activate the inactive zymogen, and control through tissue inhibitors of matrix metalloproteinases (TIMPs).

Additional Info

Additional Info

Name Recombinant Human MMP-3 (Carrier-free)
Cat. No. 21-7073
Technical Data Sheet Download TDS
Alternative Names Stromelysin-1, SL-1, Transin-1, Matrix Metalloproteinase-3
Amino Acid Sequence MRTFPGIPKW RKTHLTYRIV NYTPDLPKDA VDSAVEKALK VWEEVTPLTF SRLYEGEADI MISFAVREHG DFYPFDGPGN VLAHAYAPGP GINGDAHFDD DEQWTKDTTG TNLFLVAAHE IGHSLGLFHS ANTEALMYPL YHSLTDLTRF RLSQDDINGI QSLYGPPPDS PETPLVPTEP VPPEPGTPAN CDPALSFDAV STLRGEILIF KDRHFWRKSL RKLEPELHLI SS
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity MMP-3 activity was measured by its ability to cleave a chromogenic peptide MMP-3 substrate at room temperature. At a MMP-3 concentration of 2.5 µg/ml, 50% cleavage was achieved at an incubation time of approximately 75 minutes.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Cancer; Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.