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Recombinant Human ICAM-1 (Carrier-free)

Sizes available: 10 µg, 50 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7064
Recombinant Human ICAM-1 (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human ICAM-1 (Carrier-free) ..... Cat.No. 21-7064-U010 ..... Size 10 µg
$76.00
Recombinant Human ICAM-1 (Carrier-free) ..... Cat.No. 21-7064-U050 ..... Size 50 µg
$209.00
Recombinant Human ICAM-1 (Carrier-free) ….. Cat.No. 21-7064-U100 ….. Size 100 µg
$280.00
Recombinant Human ICAM-1 (Carrier-free) ..... Cat.No. 21-7064-U500 ..... Size 500 µg
$859.00

Description

Details

Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, is a member of the immunoglobulin (Ig) superfamily and binds the leukocyte integrins LFA-1 and Mac-1, and functions as the major receptor for human rhinovirus. LFA-1 is found on all T cells and interaction with ICAM-1 has been shown to stimulate various T cell activation and differentiation activities. ICAM-1 is expressed at low levels on the surface of leukocytes, endothelial cells, macrophages, and lymphocytes but is activated by LPS and cytokines such as IFN-gamma, TNF-alpha and IL-1beta. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury.

Additional Info

Additional Info

Name Recombinant Human ICAM-1 (Carrier-free)
Cat. No. 21-7064
Technical Data Sheet Download TDS
Alternative Names Intercellular adhesion molecule 1, major group rhinovirus receptor, CD54 antigen
Amino Acid Sequence QTSVSPSKVI LPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPGNNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFL TVYWTPERVE LAPLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVGEPA EVTTTVLVRR DHHGANFSCR TELDLRPQGL ELFENTSAPY QLQTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSE AQVHLALGDQ RL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25 µg/ml ICAM-1 concentration.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under r
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source CHO cells
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Inflammation; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.