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Recombinant Human GDNF (Carrier-free)

Sizes available: 2 µg, 10 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-8506
Recombinant Human GDNF (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human GDNF (Carrier-free) ..... Cat.No. 21-8506-U002 ..... Size 2 µg
$76.00
Recombinant Human GDNF (Carrier-free) ..... Cat.No. 21-8506-U010 ..... Size 10 µg
$199.00
Recombinant Human GDNF (Carrier-free) ….. Cat.No. 21-8506-U100 ….. Size 100 µg
$1,025.00
Recombinant Human GDNF (Carrier-free) ..... Cat.No. 21-8506-U500 ..... Size 500 µg
$2,479.00

Description

Details

Glial Cell derived Neurotrophic Factor (GDNF) is a highly conserved neurotrphic factor. It is a novel member of the TGF­beta superfamily that has been shown to promote survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of development. Upregulated expression of GNDF was observed in various cancer cell lines and correlates with malignant cancer progression, suggesting a role of GDNF in carcinogenesis. The mature form of GDNF is a secreted protein that exists as a disulfide­linked homodimeric glycoprotein.

Additional Info

Additional Info

Name Recombinant Human GDNF (Carrier-free)
Cat. No. 21-8506
Technical Data Sheet Download TDS
Alternative Names Glial-Derived Neurotrophic Factor, ATF-1
Amino Acid Sequence MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was determined by the proliferation of rat C6 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human GDNF is a disulfide-linked 30 kDa homodimer, composed of two 135 amino acid polypeptide chains.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Neurobiology; Stem Cells & Differentiation; TGF-beta Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.