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Recombinant Human Amphiregulin (Carrier-free)

Sizes available: 10 µg, 50 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7095
Recombinant Human Amphiregulin (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human Amphiregulin (Carrier-free) ..... Cat.No. 21-7095-U010 ..... Size 10 µg
$69.00
Recombinant Human Amphiregulin (Carrier-free) ..... Cat.No. 21-7095-U050 ..... Size 50 µg
$169.00
Recombinant Human Amphiregulin (Carrier-free) ..... Cat.No. 21-7095-U100 ..... Size 100 µg
$280.00
Recombinant Human Amphiregulin (Carrier-free) ..... Cat.No. 21-7095-U500 ..... Size 500 µg
$859.00

Description

Details

Amphiregulin is a glycoprotein belonging to the EGF family that includes a variety of proteins such as the Neuregulins, TGF-alpha, HB-EGF and Epiregulin. These cytokines are characterized by the presence of at least one EGF structural unit, and all are synthesized as transmembrane precursors which are proteolytically cleaved to produce a soluble form. Amphiregulin stimulates the growth and proliferation of various cell types including keratinocytes, mammary epithelial cells and some fibroblasts, and has also been shown to inhibit growth in certain carcinoma cell lines. Amphiregulin is able to bind to, and signal through, the EGF receptor.

Additional Info

Additional Info

Name Recombinant Human Amphiregulin (Carrier-free)
Cat. No. 21-7095
Technical Data Sheet Download TDS
Alternative Names AR, AREG, Colorectum cell-derived growth factor (CRDGF)
Amino Acid Sequence SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity A stimulation assay is used to determine biological activity based on the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human Amphiregulin consists of 98 amino acid residues, resulting in a 11.3 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Cancer, Inflammation, Neurobiology, Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
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Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHCF = Immunohistochemistry, Frozen Tissue; IHCP = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.