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Recombinant Human IL-10 (Carrier-free)

Sizes available: 2 µg, 10 µg, 100 µg, 500 µg

Applications: Bioassay
SKU: 21-8109
Recombinant Human IL-10 (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human IL-10 (Carrier-free) ….. Cat.No. 21-8109-U002 ….. Size 2 µg
$61.00
Recombinant Human IL-10 (Carrier-free) ….. Cat.No. 21-8109-U010 ….. Size 10 µg
$175.00
Recombinant Human IL-10 (Carrier-free) ….. Cat.No. 21-8109-U100 ….. Size 100 µg
$1,050.00
Recombinant Human IL-10 (Carrier-free) ….. Cat.No. 21-8109-U500 ….. Size 500 µg
$2,560.00

Description

Details

IL-10 is elaborated and secreted by macrophages, monocytes, T cells, B cells and keratinocytes and is well characterized as a potent immunosuppressive and anti-inflammatory cytokine. IL-10 has been shown to exert inhibitory effects on Th0, Th1 and Th2 subsets and monocytes. IL-10 has been shown also to inhibit expression of co-stimulatory molecules such as CD80 and CD86 on antigen presenting cells. IL-10 has also been shown to enhance B-cell and other responses in specific scenarios. Because of its pleiotropic role, IL-10 has been explored as a therapeutic agent in inflammatory diseases and cancer.

Additional Info

Additional Info

Name Recombinant Human IL-10 (Carrier-free)
Cat. No. 21-8109
Technical Data Sheet Download TDS
Alternative Names B-TCGF, CSIF, TGIF
Amino Acid Sequence MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was found to be 2.0 ng/ml, corresponding to a specific activity of 5 x 10^5 units/mg determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass This recombinant protein is 161 amino acid residues with a molecular weight of 18.6 kDa.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas AIDS/HIV; Cancer; Immune System; Inflammation; Neurobiology; Stem Cells & Differentiation; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
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Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHCF = Immunohistochemistry, Frozen Tissue; IHCP = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.