EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family known to strongly contract gastrointestinal (GI) smooth muscle. EG-VEGF is a secreted angiogenetic mitogen growth factor that induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. The steroidogenic glands (ovary, testis, adrenal gland, and placenta) express EG-VEGF and expression is known to be induced by hypoxia. EG-VEGF and VEGF may function in a coordinated manner as their expression is often complementary. The murine EG-VEGF gene codes for a 105 amino acid polypeptide containing an N-terminal signal sequence of 19 amino acids.