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Description
Details
Epigen is a member of the EGF superfamily of proteins that signals through the ErbB receptor-1. As are other members of the EGF superfamily, human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane-bound precursor that is proteolytically cleaved from the plasma membrane. Epigen is mitogenic for fibroblasts and epithelial cells. Although Epigen has low binding affinity to EGF receptors, it has strong mitogenic potency due to its prolonged binding presence. Expression of Epigen has been detected in multiple tissues including testis, liver and heart. Transcript and protein expression have also been reported in cancer specimens of the breast, bladder, and prostate.
Additional Info
Additional Info
| Name | Recombinant Human Epigen (Carrier-free) |
|---|---|
| Cat. No. | 21-7183 |
| Technical Data Sheet | Download TDS |
| Alternative Names | EPG, Epithelial mitogen |
| Amino Acid Sequence | AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expectedED50 for this effect is 150-300 ng/ml. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1EU/μg). |
| Molecular Mass | Recombinant Human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF-homologous portion of the Epigen precursor. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E.coli |
| Reactivity | Human |
| Research Areas | Cancer, Inflammation |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |