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Recombinant Human Endostatin (Carrier-free)

Sizes available: 20 µg, 100 µg, 500 µg, 1 mg
Applications: Bioassay
SKU: 21-7182
Recombinant Human Endostatin (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human Endostatin (Carrier-free) ..... Cat.No. 21-7182-U020 ..... Size 20 µg
$76.00
Recombinant Human Endostatin (Carrier-free) ..... Cat.No. 21-7182-U100 ..... Size 100 µg
$179.00
Recombinant Human Endostatin (Carrier-free) ..... Cat.No. 21-7182-U500 ..... Size 500 µg
$635.00
Recombinant Human Endostatin (Carrier-free) ..... Cat.No. 21-7182-M001 ..... Size 1 mg
$1,035.00

Description

Details

Endostatin is a C-terminal proteolytic fragment of collagen XVIII α1 (Col 18) that is localized in the vascular basement membrane of almost all epithelia and endothelia.Expressed in multiple organs, its highest levels of expression are in liver, lung and kidney. Endostatin is known to inhibit proliferation, migration, and tubule formation of endothelial cells and is an endogenous inhibitor of angiogenesis. Since tumor growth and metastasis relies on angiogenesis to provide blood supply, Endostatin is inhibitory for a wide variety of primary and metastatic tumors.

Additional Info

Additional Info

Name Recombinant Human Endostatin (Carrier-free)
Cat. No. 21-7182
Technical Data Sheet Download TDS
Alternative Names COL18A1
Amino Acid Sequence MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Measured by its ability to inhibit HUVEC migration.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
Molecular Mass Recombinant Human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E.coli
Reactivity Human
Research Areas Angiogenesis & Cardiovascular
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.