EGF-L7 also known as VE-Statin (vascular endothelia cell statin) is a secreted glycoprotein belonging to the family of EGF-like domain-containing proteins. EGF-L7 is a multi-domain protein containing two EGF-like domains and one EMI domain. Almost exclusively expressed in endothelial cells, it is commonly used as an early marker of embryonic endothelial cells. In adult endothelial cells, although downregulated, it is still detectable in blood vessels of lung, heart and kidney. EGF-L7’s primary function is to promote normal development of the vascular system, particularly tubulogenesis. An up-regulation of EGF-L7 is observed in endothelial cells during vascular remodeling tissues, such as regenerating endothelium of the artery and atherosclerotic plaques. EGF-L7 interacts with Notch receptors and overexpression has be shown to inhibit the Notch pathway in HUVEC and neural stem cells. In HCAEC (human coronary artery endothelial cells), EGF-L7 inhibits hypoxia/re-oxygenation, ICAM-1 expression, NF-κB nuclear translocation and decrease of IκBα expression. Additionally, EGF-L7 can chemoattract endothelial cells and bind to the extracellular matrix. Overexpression of EGF-L7 is generally correlated with increased metastasis and a poor prognosis in growing tumors.