Toll-Free Customer Service (855) 848-6626 Hours 6AM-3PM PST

FREE Shipping on orders over $500*

Your valued source for Immunology Tools

Recombinant Human ANGPTL3 (Carrier-free)

Sizes available: 10 µg, 50 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7169
Recombinant Human ANGPTL3 (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human ANGPTL3 (Carrier-free) ..... Cat.No. 21-7169-U010 ..... Size 10 µg
$76.00
Recombinant Human ANGPTL3 (Carrier-free) ..... Cat.No. 21-7169-U050 ..... Size 50 µg
$179.00
Recombinant Human ANGPTL3 (Carrier-free) ..... Cat.No. 21-7169-U100 ..... Size 100 µg
$280.00
Recombinant Human ANGPTL3 (Carrier-free) ..... Cat.No. 21-7169-U500 ..... Size 500 µg
$859.00

Description

Details

ANGPTL3 (Angiopoietin-Like Protein 3) is a secreted glycoprotein structurally related to the angiopoietin family of growth factors, but does not bind the angiopoietin-specific receptors Tie-2 or Tie-1. ANGPTL3 is expressed primarily in the liver during early liver development and throughout adulthood. It is found in full-length, C-terminal (fibrinogen-like) and N-terminal (coiled) formats in plasma. It is a lipoprotein lipase (LPL) inhibitor, promoting an increase in circulating triglyceride levels. ANGPTL3 also plays a role in angiogenesis, with the fibrinogen-like domain binding to integrin alpha V, beta 3 and inducing adhesion and migration of endothelial cells.

Additional Info

Additional Info

Name Recombinant Human ANGPTL3 (Carrier-free)
Cat. No. 21-7169
Technical Data Sheet Download TDS
Alternative Names Angiopoietin-Like Protein 3, ANGPT5, Ang-5, Angiopoietin-5, FHBL2, ANL3
Amino Acid Sequence SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TT
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ability to bind recombinant integrin alpha V, beta 3 is measured through a functional ELISA.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human ANGPTL3 contains a C-terminal His-tag and is comprised of 452 amino acids. It migrates at approximately 62 kDa by SDS-PAGE.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source CHO cells
Reactivity Human
Research Areas Diabetes, Angiogensis & Cardiovascular, Lipid Metabolism
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
Need Another Format? Inquire Here

Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.