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Recombinant Human Angiopoietin-2 (Carrier-free)

Sizes available: 5 µg, 20 µg, 100 µg, 500 µg
Applications: Bioassay
SKU: 21-7168
Recombinant Human Angiopoietin-2 (Carrier-free) is available for purchase in increments of 1
Product Name Price Qty
Recombinant Human Angiopoietin-2 (Carrier-free) ..... Cat.No. 21-7168-U005 ..... Size 5 µg
$76.00
Recombinant Human Angiopoietin-2 (Carrier-free) ..... Cat.No. 21-7168-U020 ..... Size 20 µg
$175.00
Recombinant Human Angiopoietin-2 (Carrier-free) ..... Cat.No. 21-7168-U250 ..... Size 250 µg
$1,725.00
Recombinant Human Angiopoietin-2 (Carrier-free) ..... Cat.No. 21-7168-U500 ..... Size 500 µg
$2,995.00

Description

Details

Angiopoietin-2 (ANG-2, ANGPT2) is a secreted glycoprotein belonging to the angiopoietin family of growth factors that play a critical role in the regulation of angiogenesis and vascular development. Like Angiopoietin-1, Angiopoietin-2 is a ligand for receptor tyrosine kinase Tie-2, binding with similar affinity. Angiopoietin-2 plays a role in regulating Ang-1/Tie-2 signaling, but can also act as a Tie-2 antagonist depending on its state of multimerization. In the absence of VEGF, Angiopoietin-2 promotes vessel destabilization and regression. On the contrary, in the presence of VEGF, it promotes cell proliferation and migration in endothelial cells.

Additional Info

Additional Info

Name Recombinant Human Angiopoietin-2 (Carrier-free)
Cat. No. 21-7168
Technical Data Sheet Download TDS
Alternative Names ANGPT2, ANG-2
Amino Acid Sequence DAPLEYDDSV QRLQVLENIM ENNTQWLMKL ENYIQDNMKK EMVEIQQNAV QNQTAVMIEI GTNLLNQTAE QTRKLTDVEA QVLNQTTRLE LQLLEHSLST NKLEKQILDQ TSEINKLQDK NSFLEKKVLA MEDKHIIQLQ SIKEEKDQLQ VLVSKQNSII EELEKKIVTA TVNNSVLQKQ QHDLMETVNN LLTMMSTSNS AKDPTVAKEE QISFRDCAEV FKSGHTTNGI YT
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Using a concentration of 0.2 ug/mL, a tubulogenesis assay with human umbilical vein endothelial cells (HUVECs) is performed.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Angiopoietin-2 is a 50.1 kDa glycoprotein with a C-terminal His-tag. It migrates under reducing conditions at approximately 60-70 kDa by SDS-PAGE. Based on sequencing, the N-terminus starts with residue 68 (D) of the precursor protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source CHO cells
Reactivity Human
Research Areas Apoptosis, Angiogensis & Cardiovascular, Bone and Cartidage
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Applications Bioassay
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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.