Toll-Free Customer Service (855) 848-6626 Hours 6AM-5PM PST

FREE Shipping on orders over $300*

Your valued source for Immunology Tools

PE Anti-Mouse TIGIT (1G9)

Sizes available: 25 µg, 100 µg

Applications: FC
SKU: 50-1421
Product Name Price Qty
PE Anti-Mouse TIGIT (1G9) ..... Cat.No. 50-1421-U025 ..... Size 25 µg
$69.00
PE Anti-Mouse TIGIT (1G9) ..... Cat.No. 50-1421-U100 ..... Size 100 µg
$168.00

Description

Details

The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26 kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation. Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals. TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells. Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion. A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.

The 1G9 antibody may be used for flow cytometric analysis of TIGIT, which is expressed at very high levels on T regulatory cells (Tregs) and activated conventional T cells, as well as memory T cells and NK cells.

Additional Info

Additional Info

Name PE Anti-Mouse TIGIT (1G9)
Cat. No. 50-1421
Technical Data Sheet Download TDS
Alternative Names VSTM3
Gene ID 100043314
Clone 1G9
Isotype Mouse IgG1, kappa
Reactivity Mouse
Cross Reactivity
Format PE
Applications Flow Cytometry
Citations*

Joller N, Peters A, Anderson AC, and Kuchroo VK. 2012. Immunol. Rev. 248(1):122-139. (Flow cytometry)

Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, and Kuchroo VK. 2011. J. Immunol. 186: 1338-1342. (Flow cytometry)

Need Another Format? Inquire Here

Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.