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In Vivo Ready™ Anti-Human CD28 (CD28.6)

Sizes available: 100 ug

Applications: FC, FA, WB
SKU: 40-0288
In Vivo Ready™ Anti-Human CD28 (CD28.6) is available for purchase in increments of 1
Product Name Price Qty
In Vivo Ready™ Anti-Human CD28 (CD28.6) ..... Cat.No. 40-0288-U100 ..... Size 100 µg
$79.00

Description

Details

The CD28.6 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The CD28.6 antibody is reported to have neutralizing activity and is also useful for western blotting.

Additional Info

Additional Info

Name In Vivo Ready™ Anti-Human CD28 (CD28.6)
Cat. No. 40-0288
Technical Data Sheet Download TDS
Alternative Names T44
Gene ID 940
Clone CD28.6
Isotype Mouse IgG2a, kappa
Reactivity Human
Cross Reactivity Human
Format FITC
Applications Flow Cytometry, Functional Assays, Western Blot
Citations*

Yang JH, Zhang J, Cai Q

Yang JH, Zhang J, Cai Q, Zhao DB, Wang J, Guo PE, Liu L, Han XH, Shen Q. 2005. Rheumatology (Oxford). Oct;44(10):1245-1254.

Zhang XG, Olive D, Devos J, Rebouissou C, Ghiotto-Ragueneau M, Ferlin M, Klein B. 1998. Leukemia. Apr;12(4):610-618.

Kariv I, Truneh A, Sweet RW. 1996. J Immunol. Jul 1;157(1):29-38.

Nunes J, Klasen S, Ragueneau M, Pavon C, Couez D, Mawas C, Bagnasco M, Olive D. 1993. Int Immunol. Mar;5(3):311-315.

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.