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Your valued source for Immunology Tools

Validated reagents. Trusted by your peers.

Check out what researchers around the world are doing with reagents from Tonbo Biosciences. Our flow and In Vivo Ready antibodies, buffers, and RPx Pro™ recombinant proteins are being cited in top immunology journals. We provide quality, validated reagents to support your immunology workflow - now you can read about them in a growing selection of peer reviewed articles.

Featured Citation

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

T-cell genome engineering holds great promise for cancer immunotherapies and cell-based therapies for HIV, primary immune deficiencies, and autoimmune diseases, but genetic manipulation of human T cells has been inefficient. We achieved efficient genome editing by delivering Cas9 protein pre-assembled with guide RNAs. These active Cas9 ribonucleoproteins (RNPs) enabled successful Cas9-mediated homology-directed repair in primary human T cells. Cas9 RNPs provide a programmable tool to replace specific nucleotide sequences in the genome of mature immune cells—a longstanding goal in the field. These studies establish Cas9 RNP technology for diverse experimental and therapeutic genome engineering applications in primary human T cells.

Products cited: APC CD25 (BC96), PE CD127 (R34-34), violetFluor™ CD45RA (HI100), FITC CD45RO (UCHL1)

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Anti-Human Antibodies:

CD3 (OKT3)

Poujol F, Monneret G, Friggeri A, Rimmele T, Malcus C, Poitevin-Later F, Pachot A, Lepape A, Textoris J and Venet F. 2014. Flow cytometric evaluation of lymphocyte transformation test based on 5-ethynyl-2'deoxyuridine incorporation as a clinical alternative to tritiated thymidine uptake measurement. J Immunol Methods. 415: 71-79.

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He Q, Zhang H, Wang Y, Ting HH, Yu W, Cao X and Ge W. 2014. Purified anti-CD3 x anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells. Cell Biosci. 4(1): 70.

» View on PubMed

Khan SQ, Guo L, Cimbaluk D, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A and Gupta V. 2014. A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy. Front Med (Lausanne). 1:45.

» View on PubMed

Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies. Clin Cancer Res. 21(6): 1267-1272.

» View on PubMed

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive. DOI:10.18632/oncotarget.11019

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Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056

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CD56 (NCAM) (MY31)

Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive. DOI:10.18632/oncotarget.11019

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CD5 (UCHT2)

Chen KH, Wada M, Firor AE, Pinz KG, Jares A, Liu H, Salman H, Golightly M, Lan F, Jiang X and Ma Y. 2016. Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies. Oncotarget. DOI: 10.18632/oncotarget.11019

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CD11b (M1/70)

Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S and Williams JV. 2015. Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol. 89(8): 4405-4420.

» View on PubMed

Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

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Molina-Sanchez P, Chevre R, Rius C, Fuster JJ and Andres V. 2015. Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK. J Mol Cell Cardiol. 84: 84-94.

» View on PubMed

O'Sullivan TE, Johnson LR, Kang HH, Sun JC. 2015. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 43: 331-342.

» View on PubMed

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

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Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

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Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

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Dill R and Walker AM. 2016. Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland. J. Mammary Gland Biol. Neoplasia. doi: 10.1007/s10911-016-9369-0

» View on PubMed

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed


CD19 (HIB19)

Yoshia Y, Ogata A, Kang S, Ebina K, Shi K, Nojima S, Kimura T, Ito D, et al. 2015. Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications. Arthritis Rheumatol. 67(6): 1481-1490.

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Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Price AA, Tedesco D, Prasad MR, Workowski KA, Walker CM, Suthar MS, Honegger JR and Grakoui A. 2016. Prolonged Activation of Innate Antiviral Gene Signature After Childbirth is Determined by IFNL3 Genotype. Proc Natl Acad Sci USA doi: 10.1073/pnas.1602319113

» View on PubMed


CD27 (O323)

Wilson RM, Marshall NE, Jeske DR, Purnell JQ, Thornburg K and Messaoudi I. 2015. Maternal Obesity alters immune cell frequencies and responses in umbilical cord blood samples. Pediatr Allergy Immunol. 26(4): 344-351.

» View on PubMed

Cantisan S, Paez-Vega A, Perez-Romero P, Montejo M, Cordero E, Gracia-Ahufinger I, Martin-Gandul C, Maruri N, Aguado R, Solana R and Torre-Cisneros J. 2016. Prevention Strategies Differentially Modulate the Impact of Cytomegalovirus Replication on CD8+ T-cell Differentiation in High-Risk Solid Organ Transplant Patients. Antiviral Research. doi:10.1016/j.antiviral.2016.06.012

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CD44 (IM7)

Nakamachi T, Sugiyama K, Watanabe J, Imai N, Kagami N, Hori M, Arata S and Shioda S. 2014. Comparison of Expression and Proliferative Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its Receptors on Human Astrocytoma Cell Lines J Mol Neurosci. 54(3): 388-394.

» View on PubMed

Schwerk A, Altshuler J, Roch M, Gossen M, Winter C, Berg J, Kurtz A, Akyuz L and Steiner B. 2015. Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regen Med. 10(4): 431-445.

» View on PubMed


CD45 (HI30)

Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies. Clin Cancer Res. 21(6): 1267-1272.

» View on PubMed

Ogata Y, Mabuchi Y, Yoshida M, Suto EG, Suzuki N, Muneta T, Sekiya I and Akazawa C. 2015. Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration. PLoS One. 10.1371/journal.pone.0129096.

» View on PubMed

Mei HE, Leipold MD and Maecker HT. 2015. Platinum-conjugated antibodies for application in mass cytometry. Cytometry A. DOI: 10.1002/cyto.a.22778.

» View on PubMed

Shen Z, Rodriguez-Garcia M, Patel MV, Barr FD and Wire CR. 2016. Menopausal Status Influences the Expression of Programmed Death (PD)-1 and its Ligand PD-L1 on Immune Cells from the Human Female Reproductive Tract. American Journal of Reproductive Immunology. DOI: 10.1111/aji.12532

» View on PubMed

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C and Wira CR. 2016. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Dartmouth. Immunol. doi:10.1038/mi.2016.72 199

» View on PubMed


CD127 (R34-34)

Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR and Kusunoki Y. 2014. Linkage between Dendritic and T Cell Commitments in Human Circulating Hematopoietic Progenitors. J Immunol. 192(12): 5749-5760.

» View on PubMed


CD3 (SK7)

Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

» View


CD3 (UCHT1)

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Chi S, Weiss A and Wang H. 2015. A CRISPR-based Toolbox For Studying T Cell Signal Transduction. BioMed Res Int. DOI:10.1155/2016/5052369

» View

Locci M, Wu JE, Arumemi F, Mikulski Z, Dahlberg C, Miller AT and Crotty S. 2016. Activin A Programs the Differentiation of Human TFH Cells. Nature Immunology. doi:10.1038/ni.3494

» View on PubMed

Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ and Marson A. 2016. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. doi: 10.1016/j.celrep.2016.09.080.

» View on PubMed

Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM and Monson NL. 2016. CD40 Mediated NF-kB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J. Immunol. doi:10.4049/jimmunol.1600782

» View


CD4 (RPA-T4)

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Dillon, SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, and Wilson CC. 2016. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. DOI 10.1186/s12977-016-0237-1

» View on PubMed

Arnold N, Girke T, Sureshchandra S and Messaoudi I. 2016. Acute simian varicella infection causes robust and sustained changes in gene expression in the sensory ganglia. J. Virol. doi: 10.1128/JVI.01272-16

» View on PubMed

Viisanen T, Ihantola E, Nanto-Salonen K, Hyoty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamaki J, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. 2016. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. DOI: 10.2337/db16-0714

» View

Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM and Monson NL. 2016. CD40 Mediated NF-kB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J. Immunol. doi:10.4049/jimmunol.1600782

» View

Rudloff I, Cho SX, Lao JC, Ngo D, McKenzie M, Nold-Petry CA and Nold MF. 2016. Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells. J. Leukoc. Biol. doi:10.1189/jlb.3MA0616-287R

» View on PubMed


CD8a (RPT-T8)

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Dillon, SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, and Wilson CC. 2016. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. DOI 10.1186/s12977-016-0237-1

» View on PubMed


CD28 (CD28.2)

Chi S, Weiss A and Wang H. 2015. A CRISPR-based Toolbox For Studying T Cell Signal Transduction. BioMed Res Int. DOI:10.1155/2016/5052369

» View

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ and Marson A. 2016. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. doi: 10.1016/j.celrep.2016.09.080.

» View on PubMed

Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056

» View

Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H,Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N and Walker BD. 2016. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genet. doi:10.1038/ng.3741

» View on PubMed


CD45RA (HI100)

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Viisanen T, Ihantola E, Nanto-Salonen K, Hyoty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamaki J, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. 2016. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. DOI: 10.2337/db16-0714

» View


CD161 (HP-3G10)

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View


CD25 (BC96)

Ryotokuji K, Nakajima T, Ishimaru K, Ozaki-Shimada A, Kihara K, Namiki Y and Otani S. 2015. Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells. Laser Therapy. 24(3): 179-188.

» View

Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

» View on PubMed

Cheng H, Gaddis DE, Wu R, McSkimming C, Haynes LD, Taylor AM, McNamara CA, Sorci-Thomas M and Hedrick CC. 2016. Loss of ABCG1 Influences Regulatory T Cell Differentiation and Atherosclerosis. J. Clin. Invest. doi:10.1172/JCI83136.

» View on PubMed


Clones not Specified

Kobayashi E, Kishi H, Ozawa T, Horii M, Hamana H, Nagai T and Muraguchi A. 2014. Retroviral vectors for homologous recombination provide efficient cloning and expression in mammalian cells. Biochem Biophys Res Commun. 444(3): 319-324.

» View on PubMed

Steiner S, Daniel C, Fischer A, Atreya I, Hirschmann S, Waldner M, Neumann H, Neurath M, Atreya R and Weigmann B. 2014. Cyclosporine A Regulates Pro-Inflammatory Cytokine Production in Ulcerative Colitis. Arch Immunol Ther Exp (Warsz). 63(1): 53-63.

» View on PubMed

Abraham S, Choi JG, Ye C, Manjunath N and Shankar P. 2014. IL-10 exacerbates xenogeneic GVHD by inducing massive human T cell expansion. Clin Immunol. 156(1): 58-64.

» View on PubMed

Clarke EV, Weist BM, Walsh CM and Tenner AJ. 2015. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 97(1): 147-160.

» View on PubMed

Harper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasenkrug KJ, Dittmer U, Wilson CC and Santiago ML. 2015. Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms. PLoS Pathog. doi: 10.1371/journal.ppat.1005254.

» View on PubMed


CD45RO (UCHL1)

Galindo-Albarran AO, Lopez-Portales OH, Gutierrez-Reyna DY, Rodriguez-Jorge O, Sanchez-Villanueva JA, Ramirez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernandez-mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S and Santana MA. 2016. CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Rep. doi: 10.1016/j.celrep.2016.10.056

» View

CD11b (ICRF44)

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C and Wira CR. 2016. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Mucosal. Immunol. doi:10.1038/mi.2016.72 199

» View on PubMed


Buffers:

Flow cytometry Perm Buffer (10X), TNB-1213

Colombo E, Tentorio P, Musio S, Rajewsky K, Pedotti R, Casola S and Farina C. 2014. Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity. Clin Exp Immunol. 176(1): 58-65.

» View on PubMed

Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

» View on PubMed


Foxp3/Transcription Factor Staining Buffer Kit, TNB-0607

Lambracht-Washington D and Rosenberg RN. 2014. A non-inflammatory immune response in aged DNA Aβ42 immunized mice supports its safety for possible use as immunotherapy in AD patients. doi:10.1016/j.neurobiolaging.2014.12.011

» View on PubMed

Karo JM, Schatz DG and Sun JC. 2014. The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells. Cell. 159(1): 94-107.

» View on PubMed

Yasuoka T, Kuwahara M, Yamada T, Maruyama S, Suzuki J, Taniguchi M, Yasukawa M, and Yamashita M. 2016. The Transcriptional Repressor Gfi1 Plays a Criticol Role in the Development of NKT1- and NKT2- Type iNKT Cells. PLOS One. doi:10.1371/journal.pone.0157395

» View on PubMed

Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Saho M, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T and Yamashita M. 2016. Bach2–Batf Interactions Control Th2-type Immune Response by Regulating the IL-4 Amplification Loop. Nat. Commun. doi:10.1038/ncomms12596

» View on PubMed

Kalokhe AS, Ibegbu CC, Kaur SP, Amara RR, Kelley ME, Rio C and Stephenson R. 2016. Initimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women. Pathog. Immun. doi: 10.20411/pai.v1i1.120

» View on PubMed


Foxp3/Transcription Factor Fix/Perm Concentrate (4X), TNB-1020

Li X, Li Z, Hou D, Zhao Y, Wang C and Li X. 2016. The bovine endometrial epithelial cells promote the differentiation of trophoblast stem-like cells to binucleate trophoblast cells. Cytotechnology. DOI: 10.1007/s10616-016-9994-x

» View on PubMed


Viability Dyes:

7-AAD

Kamachi F, Isshiki T, Harada N, Akiba H and Miyake S. 2015. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2015.06.005.

» View on PubMed

Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zhou JZ, El-Hage NG, Deng J, Lin J, Yao F, Dewar III RS, Jassal JS, Sandberg ML, Dai J, Cols M, Shen C, Polin LA, Nichols RA, Jones TB, Bluth MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei WZ, Cerutti A, Colonna M and Chen K. 2016. Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Nat. Med. doi:10.1038/nm.4244

» View on PubMed


Ghost Dye™ Fixable Viability Dyes

Vo H, Chiu J, Allaimo D, Mao C, Wang Y, Gong Y, Ow H, Porter T and Zhong X. 2014. High fat diet deviates PtC-specific B1 B cell phagocytosis in obese mice. Immun Inflamm Dis. 2(4): 254-261.

» View on PubMed

Kholer SL, Pham MN, Folkvord JM, Arends T, Miller SM, Miles B, Meditz AL, McCarter AM, Levy DN and Connick E. 2016. Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication. J Immunol. doi: 10.4049/jimmunol.1502174.

» View on PubMed

Thompson EA, Beura LK, Nelson CE, Anderson KG, and Vezys V. 2016. Shortened Intervals during heterologous Boosting Preserve Memory CD8 T Cell Function but Compromise Longevity. The Journal of Immunology. doi:10.4049/jimmunol.1501797

» View on PubMed

Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

» View on PubMed

DiNardo AR, Mandalakas AM, Maphalala G, Mtetwa G, Mndebele T, Ustero P, Hlatshwayo M, Mace EM, Orange JS and Makedonas G. 2016. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators Inflamm. http://dx.doi.org/10.1155/2016/1478340

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Wood S, Feng J, Chung J, Radojcic V, Sandy-Sloat AR, Friedman A, Shelton A, Yan M, Siebel CW, Bishop DK and Maillard I. 2015. Transient Blockade of Delta-like Notch Ligands Prevents Allograft Rejection Mediated by Cellular and Humoral Mechanisms in a Mouse Model of Heart Transplantation. J Immunol. 194(6): 2899-2908.

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Burger ML, Leung KK, Bennett, MJ and Winoto A. 2014. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. eLife 2014;10.7554/eLife.03468.

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Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcaqic N et al. 2015. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 125 (4): 591-599.

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Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

» View on PubMed

Rao PS and Kumar S. 2016. Chronic Effects of Ethanol and/or Darunavir/Ritonavir on U937 Monocytic Cells: Regulation of Cytochrome P450 and Antioxidant Enzymes, Oxidative Stress, and Cytotoxicity. Alcohol Clin Exp Res. 40(1): 73-82.

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Lee AR, Mao C, Vo H, Gao W and Zhong X. 2015. Fluorescence tagging and inducible depletion of PD-L2-expressing B-1 B cells in vivo. Ann NY Acad Sci. doi: 10.1111/nyas.12865.

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Miles B, Miller SM, Folkvord JM, Kimball A, Chamanian M, Meditz AL, Arends T, McCarter MD, Levy DN, Rakasz EG, Skinner PJ and Connick E. 2015. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. doi: 10.1038/ncomms9608.

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

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Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

» View on PubMed

Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA and Jenkins MK. 2016. Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. doi: 10.1038/ni.3327.

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Guthmiller JJ, Zander RA and Butler NS. 2015. Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice. Methods Mol Biol. 1325: 19-37.

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Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casy KA, Thompson EA, Fraser KA, Rosator PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining N, Jameson SC, and Masopust D. 2016. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature. doi:10.1038/nature17655

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Larsen IV, Clausius H, Kolb AW, and Brandt CR. 2016. Both CD8+ and CD4+ T-Cells Contribute to Corneal Clouding and Viral Clearance Following Vaccinia Virus Infection in C57BL/6 Mice. Journal of Virology. doi: 10.1128/JVI.00570-16

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Flores-Fernandez R, Blanco-Favela F, Fuentes-Panama EM, Chavez-Sanchez L, Gorocica-Rosete P, Pizana-Venegas A, and Chavez-Rueda AK. 2016. Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking. Journal of Immunology Research. doi:10.1155/2016/3219017

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Gavino AC, Nahmod K, Bharadwaj U, Makedonas G, and Tweardy DJ. 2016. STAT3 Inhibition Prevents Lung Inflammation, Remodeling, and Accumulation of Th2 and Th17 Cells in a Murine Asthma Model. Experimental Allergy and Immunology. DOI: 10.1111/all.12937

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

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Malo CS, Renner DN, Huseby Kelcher AM, Jin F, Hansen MJ, Pavelko KD and Johnson AJ. 2016. The Effect of Vector Silencing During Picornavirus Vaccination Against Experimental Melanoma and Glioma. PLoS One. doi:10.1371/journal.pone.0162064

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Zhang B, Kwon O, Henry G, Strand DW, Ittmann MM and Xin L. 2016. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Molecular Cell 63, 976–989. http://dx.doi.org/10.1016/j.molcel.2016.07.025

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Cumba Garcia LM, Huseby Kelcher AM, Malo CS and Johnson AJ. 2016. Superior Isolation of Antigen-Specific Brain Infiltrating T Cells Using Manual Homogenization Technique. J. Immunol. Methods doi: 10.1016/j.jim.2016.09.002

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Ranjit S, Middle NM, Sinha N, Patters BJ, Rahman MA, Cory TJ, Rao PSS and Kumar S. 2016. Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways. PloS one. doi: 10.1371/journal.pone.0163827

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Boisvert M, Zhang W, Elrod EJ, Bernard NF, Villeneuve JP, Bruneau J, Marcotrigiano J, Shoukry NH and Grakoui A. 2016. Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells. J. Immunol. doi: 10.4049/​jimmunol.1600763

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Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zhou JZ, El-Hage NG, Deng J, Lin J, Yao F, Dewar III RS, Jassal JS, Sandberg ML, Dai J, Cols M, Shen C, Polin LA, Nichols RA, Jones TB, Bluth MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei WZ, Cerutti A, Colonna M and Chen K. 2016. Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Nat. Med. doi:10.1038/nm.4244

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Gasper DJ, Neldner B, Plisch EH, Rustom H, Carrow E, Imai H, Kawaoka Y and Suresh M. 2016. Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines. PLoS Pathog. doi:10.1371/journal.ppat.1006064

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Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

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Isotype Controls:

MOPC-21

Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G and Greenhouse B. 2015. PLoS Pathog. doi: 10.1371/journal.ppat.1004894.

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Rat IgG1

Manlove LS, Berguam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK and Farrar MA. 2015. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol. 195(8): 40208-4037.

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Hang Q, Isaji T, Hou S, Im S, Fukuda T and Gu J. 2015. Integrin α5 suppresses the phosphorylation of epidermal growth factor receptor and its cellular signaling of cell proliferation via N-glycosylation. J Biol Chem. doi: 10.1074/jbc.M115.682229.

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Rat IgG2a

Manlove LS, Berguam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK and Farrar MA. 2015. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol. 195(8): 40208-4037.

» View on PubMed

Sato K, Honda S, Shibuya A and Shibuya K. Improved Protocol for Isolation of Naïve Follicular Dendritic Cells. 2016. Mol. Immunol. doi: 10.1016/j.molimm.2016.09.011

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Recombinant Proteins:

Recombinant Human IL-6 (Carrier-free)

Nishibayashi R, Inoue R, Harada Y, Watanabe T, Makioka Y and Ushida K. 2015. RNA of Enterococcus faecalis Strain EC-12 Is a Major Component Inducing Interleukin-12 Production from Human Monocytic Cells. PLoS One. 10.1371/journal.pone.0129806.

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IFN-gamma

Zander RA, Obeng-Adjei N, Guthmiller JJ, Kulu DI, Li J, Ongoiba A, Traore B, Crompton PE and Butler NS. 2015. PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host Microbe. 17(5): 628-641.

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PCR Kits

FastPROBE qPCR Hi-ROX Master Mix

Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

» View


FastSCRIPT cDNA Synthesis Kit

Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

» View


Caspase Inhibitors

Q-VD-OPH

Alam M, Kariya R, Kawaguchi A, Matsuda K, Kudo E and Okada S. 2016. Inhibition of Autophagy by Chloroquine Induces Apoptosis in Primary Effusion Lymphoma In Vitro and In Vivo Through Induction of Endoplasmic Reticulum Stress. Apoptosis. Volume 21(10), pp 1191–1201

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Montero JA, Sanchez-Fernandez C, Lorda-Diez CI, Garcia-Porrero JA and Hurle JM. 2016. DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos. Sci. Rep. doi:10.1038/srep35478

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Anti-Mouse Antibodies:

CD3 (17A2)

Hirao H, Uchida Y, Kadono K, Tanaka H, Niki T, Yamauchi A, Hata K, Watanabe T, Terajima H and Uemoto S. 2015. The protective function of galectin-9 in liver ischemia and reperfusion injury in mice. Liver Transpl. doi: 10.1002/lt.24159.

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Perez J, Dansou B, Herve R, Levi C, Tamouza H, Vandermeersch S, Demey-Thomas E, Haymann JP, Zafrani L, Klatzmann D, Boissier MC, Letavernier E and Baud L. 2015. Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression. J Immunol. doi: 10.4049 jimmunol.1500749.

» View on PubMed

Arellano B, Hussain R, Miller-Little WA, Herndon E, Lambracht-Washington D, Eagar TN, Lew R, Healey D, Vernino S, Greenberg BM, and Stuve O. 2016. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB103:01 by a Murine TCR. PLoS ONE 11(4): e0152720.doi:10.1371/journal.pone.0152720

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Han Z, Brown JR, and Niederkorn. 2016. Growth and Metastasis of Intraocular Tumors in Aged Mice. Investigative Opthalmology & Visual Science. 57:2366-2376 DOI:10.1167/iovs.16-19156

» View on PubMed

Shen Z, Rodriguez-Garcia M, Patel MV, Barr FD and Wire CR. 2016. Menopausal Status Influences the Expression of Programmed Death (PD)-1 and its Ligand PD-L1 on Immune Cells from the Human Female Reproductive Tract. American Journal of Reproductive Immunology. DOI: 10.1111/aji.12532

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Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M and Yamashita M. 2016. Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection. J. Immunol. doi: 10.4049/​jimmunol.1502295

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Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

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Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H,Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N and Walker BD. 2016. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genet. doi:10.1038/ng.3741

» View on PubMed

Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

» View on PubMed


CD3e (145-2C11)

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Van Vo A, Takenaka E, Shibuya A and Shibuya K. 2015. Expression of DNAM-1 (CD226) on inflammatory monocytes. Mol Immunol. 69: 70-76.

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Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

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Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

» View on PubMed

Iwahashi C, Fujimoto M, Nomura S, Serada S, Nakai K, Ohguro N, Nishida K and Naka T. 2015. CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: comparison with blockade of interleukin-6. Exp Eye Res. doi: 10.1016/j.exer.2015.08.012.

» View on PubMed

Neyt K, GeurtsvanKessel CH and Lambrecht BN. Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells. 2015. Mucosal Immunol. DOI 10.1038/mi2015.91.

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Giuilliams M, Dutertre C, Scott CL, McGovern N, Sichien D, Chakarov S, Gassen SV, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GH, Chung TJ, Chan DK, Tan KK, Hon TL, Fossum E, Bogen B, Choolani M, Chan JK, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B and Ginhoux F. 2016. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Immunity. doi: 10.1016/j.immuni.2016.08.015

» View on PubMed

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed


CD4 (RM4-5)

Bally APR, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R and Boss JM. 2015. NF-ΚB Regulates PD-1 Expression in Macrophages. J Immunol. 194(9): 4545-4554.

» View on PubMed

Levine AG, Arvey A, Jin W and Rudensky AY. 2014. Continuous requirement for the TCR in regulatory T cell function. Nature Immunol. 15(11): 1070-1078.

» View on PubMed

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Produhomme T, Duong B, Whang MI, Advincula R, Agelidis A, et al. 2015. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16(6): 618-627.

» View on PubMed

Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

» View on PubMed

Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

» View on PubMed

Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H and Yoshimura A. 2015. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 212(10): 1623-1640.

» View on PubMed

Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

» View on PubMed


CD4 (GK1.5)

Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H and Nakamura A. 2015. A critical rold of Dectin-1 in hypersensitivity pneumonitis. Inflamm Res. DOI 10.1007/s00011-015-0910-1.

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

» View on PubMed

Cruz-Adalia A, Ramirez-Santiago G, Torres-Torresano M, Garcia-Ferreras R and Veiga Chacon E. 2016.T Cells Capture Bacteria by Transinfection from Dendritic Cells. J Vis Exp. (107), e52976, doi: 10.3791/52976

» View on PubMed

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H and Yanagita M. 2016. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1(11):e87680. doi:10.1172/jci.insight.87680.

» View

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed


CD8a (53-6.7)

Kersh AE, Edwards LJ and Evavold BD. 2014. Progression of Relapsing-Remitting Demyelinating Disease Does Not Require Increased TCR Affinity or Epitope Spread. J. Immunol. 193(9): 4429-4438.

» View on PubMed

Bally APR, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R and Boss JM. 2015. NF-ΚB Regulates PD-1 Expression in Macrophages. J Immunol. 194(9): 4545-4554.

» View on PubMed

Han BY, Wu S, Foo C-S, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC and Cyster JG. 2014. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. eLife doi: 10.7554/eLife.03549

» View on PubMed

Martinez RJ, Neeld DK and Evavold BD. 2015. Identification of T cell clones without the need for sequencing. J Immunol Methods. doi: 10.1016/j.jim.2015.04.018.

» View on PubMed

Weist BM, Kurd N, Boussier J, Chan SW and Robey EA. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 16(6): 635-641.

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

» View on PubMed

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049/​jimmunol.1502126.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Martin SD, Brown SD, Wick DA, Nielsen JS, Kroeger DR, Twumasi-Boateng K, Holt RA, and Nelson BH. 2016. Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines. PLoS ONE. doi:10.1371/journal.pone.0155189

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Asirvatham-Jeyaraj N, Fiege JK, Han R, Foss J, Banek CT, Burbach BJ, Razzoli M, Bartolomucci A, Shimizu Y, Panoskaltsis-Mortari A and Osborn JW. 2016. Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice. Hypertensions AHA. doi: 10.1161/HYPERTENSIONAHA.116.07993

» View

Rampuria P, Lang GA, Devera TS, Gilmore C, Ballard JD, Lang ML. 2016. Coordination between T helper cells, iNKT cells, and their follicular helper sub-sets in the humoral immune response against Clostridium difficile toxin B. J Leukoc Biol. doi:10.1189/jlb.4A0616-271R

» View on PubMed

Bally APR, Tang Y, Lee JT, Barwick BG, Martinez R, Evavold BD and Boss JM. 2016. Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. J. Immunol. doi: 10.4049/​jimmunol.1601464

» View on PubMed

Ma C, Mishra S, Demel EL, Liu Y and Zhang N. 2016. TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation. J. Immunol. doi: 10.4049/​jimmunol.1601500

» View on PubMed


CD11b (M1/70)

Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, et al. 2013. TIM-4 Has Dual Function in the Induction and Effector Phases of Murine Arthritis. J Immunol. 191(9): 4562-4572.

» View on PubMed

Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

» View on PubMed

Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

» View on PubMed

Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S and Williams JV. 2015. Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol. 89(8): 4405-4420.

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

» View on PubMed

Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

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Dill R and Walker AM. 2016. Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland. J. Mammary Gland Biol. Neoplasia. doi: 10.1007/s10911-016-9369-0

» View on PubMed

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y and Tian XY. 2016. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. doi:10.1096/fj.201601030R

» View on PubMed


CD8a (2.43)

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H and Yanagita M. 2016. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1(11):e87680. doi:10.1172/jci.insight.87680.

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CD11c (N418)

Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, and Arita M. 2014. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J. 28(9): 4036-4043.

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Goshima F, Esaki S, Luo C, Kamakura M, Kimura H, and Nishiyama Y. 2014. Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer. Int J Cancer. 134(12): 2865-2877.

» View on PubMed

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M and Kanehiro A. 2015. Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00087.2015.

» View

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Beamer, GL, Seaver, BP, Jessop F, Shepherd DM, and Beamer CA. 2016. Acute Exposure to Crystalline Silica Reduces Macrophage Activation in Response to Bacterial Lipoproteins. Front Immunol. Volume 7: doi: 10.3389/fimmu.2016.00049

» View on PubMed

Li J, Lu E, Yi T, and Cyster JG. 2016. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. doi:10.1038/nature17947

» View on PubMed

Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI:10.1016/j.celrep.2016.07.037

» View on PubMed

Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

» View on PubMed

Coleman CM, Sisk JM, Halasz G, Zhong J, Beck SE, Matthews KL, Venkataraman T, Rajagopalan S, Kyratsous CA and Frieman MB. 2016. CD8+ T cells and Macrophages Regulate Pathogenesis in a Mouse Model of MERS-CoV Disease. J. Virol. doi: 10.1128/JVI.01825-16

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Olguin-Alor R, de la Fuente-Granada M, Bonifaz LC, Antonio-Herrara L, Garcia-Zepada EA and Soldevilla G. 2016. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLOS one. doi:10.1371/journal.pone.0167813

» View on PubMed

Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L and Tontonoz P. 2016. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. doi: 10.1016/j.immuni.2016.11.008

» View on PubMed


CD16/CD32 (2.4G2)

Shim YR and Lee HK. 2015. Caspase-1 Independent Viral Clearance and Adaptive Immunity Against Mucosal Respiratory Syncytial Virus Infection. Immune Netw. 15(2): 73-82.

» View on PubMed

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Oh JE, Lee MS, Kim YJ and Lee HK. 2016. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. doi: 10.1038/srep19089.

» View on PubMed

Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

» View on PubMed

Ishizuka M, Miyazaki Y, Masuo M, Shuara K, Tateishi T, Yasui M and Inase N. Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis. 2015. PLoS One. doi: 10.1371/journal.pone.0137978.

» View on PubMed

Ohta T, Sugiyama, M, Hemmi, H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii K, Hoshino K, Ginhoux F, and Kaisho T. 2016. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 6, 23505; doi: 10.1038/srep23505

» View on PubMed

Miyata Y, Otsuki M, Kita S and Shimomura I. 2016. Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells. Sci Rep. 6:21041. doi: 10.1038/srep21041.

» View on PubMed

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049 jimmunol.1502126.

» View on PubMed

Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

» View on PubMed

Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

» View on PubMed

Mula RVR, Machiah D, Holland L, Wang X, Parihar, H, Sharma AC, Selvaraj P, and Shashidharamurthy R. 2016. Immune Complex-Induced Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes is Prevented with Decoy FcγReceptors. PLoS ONE 11(4):e0153620. doi:10.1371/journal.pone.0153620

» View on PubMed

Yokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, and Minatoguchi S. 2016. Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PloS ONE. doi:10.1371/journal.pone.0154994

» View on PubMed

Nabekura T and Lanier LL. 2016. Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection. Immunity. Volume 45 , Issue 1 , 74 - 82

» View on PubMed

Murphy S, Patrick K, Thoner T, Edwards RW and Gubbels Bupp MR. 2016. T cell up-regulation of CD127 is associated with reductions in the homeostatic set point of the peripheral Tcell pool during malnourishment. Biochemistry and Biophysics Reports. doi:10.1016/j.bbrep.2016.06.006

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Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

» View on PubMed

Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N and Liu Z. 2016. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB. J. Immunol. doi: 10.4049/​jimmunol.1600690

» View on PubMed

Sato K, Honda S, Shibuya A and Shibuya K. Improved Protocol for Isolation of Naïve Follicular Dendritic Cells. 2016. Mol. Immunol. doi: 10.1016/j.molimm.2016.09.011

» View on PubMed


CD19 (1D3)

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M and Kanehiro A. 2015. Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00087.2015.

» View

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. doi: 10.7554/eLife.08088.

» View on PubMed

Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M and Kannegant T. 2016. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. doi: 10.1016/j.cell.2016.09.012

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Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL and Badovinac VP. 2016. Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J. Immunol. doi: 10.4049/​jimmunol.1601463

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Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K and Yasutomo K. 2016. Survival of mature T cells depends on signaling through HOIP. Sci Rep. doi:10.1038/srep36135

» View on PubMed

Forster M, Farrington K, Petrov JC, Belle JI, Mindt BC, Witalis M, Duerr CU, Fritz JH and Nijnik A. 2016. MYSM1-dependent checkpoints in B cell lineage differentiation and B cell–mediated immune response. J. Leukoc. Biol. doi:10.1189/jlb.1AB0415-177RR

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Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL and Stowe AM. 2015. Stroke Induces a Rapid Adaptive Autoimmune Response to Novel Neuronal Antigens. Discov. Med. (106):381-92

» View on PubMed


CD25 (PC61.5)

Martinez-Lopez M, Iborra S, Conde-Garrosa R and Sancho D. 2014. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 45(1): 119-129.

» View on PubMed

Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL and Stowe AM. 2015. Stroke Induces a Rapid Adaptive Autoimmune Response to Novel Neuronal Antigens. Discov. Med. (106):381-92

» View on PubMed


CD44 (IM7)

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

» View on PubMed

Schwerk A, Altshuler J, Roch M, Gossen M, Winter C, Berg J, Kurtz A, Akyuz L and Steiner B. 2015. Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regen Med. 10(4): 431-445.

» View on PubMed

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049 jimmunol.1502126.

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed


CD45R (B220) (RA3-6B2)

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Come C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimental JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Chen Z, Lahesmaa R, and Westermarck J. 2016. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4):e0152996. doi:10.1371/journal.pone.0152996

» View on PubMed

Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

» View on PubMed

Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

» View on PubMed

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

» View


CD45 (30-F11)

Liao W, Pham V, Liu L, Riazifar M, Pone EJ, Zhang SX, Ma F, Lu M, Walsh CM and Zhao W. 2015. Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials. doi:10.1016/j.biomaterials.2015.11.005

» View on PubMed

Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation. J Vis Exp. (107), e53638, doi:10.3791/53638.

» View on PubMed


CD45.1 (A20)

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

» View on PubMed

Miro-Mur F, Perez-de Puig I, Ferrer-Ferrer M, Ura X, Justicia C, Chamorro A and Planas AM. 2015. Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features ofalternative activation. Brain Behav Immun. doi: 10.1016/j.bbi.2015.08.010.

» View on PubMed

Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW and Blurton-Jones M. 2016. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1525466113.

» View on PubMed

Benck, CJ, Martinov, T, Fife, BT, and Chatterjea, D. 2016. Isolation of infiltrating leukocytes from mouse skin using enzymatic digest and gradient separation. J Vis Exp. (107) e53638, doi: 10.3791/53638 (2016)

» View on PubMed

Barwick BG, Scharer CD, Bally APR and Boss JM. 2016. Plasma Cell Differentiation is Coupled to Division-Dependent DNA Hypomethylation and Gene Regulation. Nat Immunol. 17(10):1216-25

» View on PubMed


CD45.2 (104)

Kamimura Y and Lanier LL. 2015. Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage. Cell Rep. 10(2): 280-291.

» View on PubMed

Martinez-Lopez M, Iborra S, Conde-Garrosa R and Sancho D. 2014. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 45(1): 119-129.

» View on PubMed

Fiege JK, Burback Bj and Shimizu Y. 2015. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 195(7): 3119-3128.

» View on PubMed

Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

» View on PubMed

Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT and Williams IR. 2015. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. doi: 10.1038/mi.2015.121.

» View on PubMed

Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

» View on PubMed

Paul D, Baena V, Ge S, Jiang X, Jellison ER, Kiprono T, Agalliu D and Pachter JS. 2016. Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. J. Neuroinflammation DOI: 10.1186/s12974-016-0755-8

» View on PubMed

Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, anania F and Grakoui A. 2016. CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease. Hepatology. doi:10.1002/hep.28894

» View on PubMed


CD62L (MEL-14)

Pannu J, Belle JI, Forster M, Duerr CU, Shen S, Kane L, Harcourt K, Fritz JH, Clare S and Nijnik A. 2015. Ubiquitin Specific Protease 21 Is Dispensable for Normal Development, Hematopoiesis and Lymphocyte Differentiation. PloS one.10(2):e0117304.

» View on PubMed

Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, et al. 2014. Transgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responses. PloS one. 9(1): e84895.

» View on PubMed

Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

» View on PubMed

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed

Anstadt EJ, Fujiwara M, Wasko N, Nichols F and Clark RB. 2016. TLR Tolerance as a Treatment for Central Nervous System Autoimmunity. J. Immunol. doi: 10.4049/​jimmunol.1600876

» View on PubMed


CD80 (16-10A1)

Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

» View


CD86 (GL-1)

Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN-γ secretion. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790

» View

Olguin-Alor R, de la Fuente-Granada M, Bonifaz LC, Antonio-Herrara L, Garcia-Zepada EA and Soldevilla G. 2016. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLOS one. doi:10.1371/journal.pone.0167813

» View on PubMed

Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L and Tontonoz P. 2016. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. doi: 10.1016/j.immuni.2016.11.008

» View on PubMed


CD90.2 (30-H12)

Majhi RK, Sahoo SS, Yadav M, Pratheek BM, Chattopadhyay S and Goswami C. 2015. Functional Expression of TRPV Channels in T cells And Their Implications in Immune Regulation. FEBS J. doi: 10.1111/febs.13306.

» View on PubMed


CD127 (Il-7Ra) (A7R34)

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

» View on PubMed


CD127 (A7R34)

Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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CD152 (CTLA-4) (UC10-4F10-11)

Yoshida Y, Mikami N, Matsushima Y, Otani F, Miyawaki M, Takatsuji M, Banno R, Tsuji T, Fujita T, Tsujikawa K and Kohno T. 2015. Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model. Biol Pharm Bull. DOI:10.1248/bpb.b14-00873.

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Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR and Joyce S.2016. A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Reports. DOI: 10.1016/j.celrep.2016.07.037

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CD274 (PD-L1, B7-H1) (10F.9G2)

Iraolagoitia XL, Spallanzani RG, Torres NI, Araya RA, Ziblat A, Domaica CI, Sierra JM, Nunex SY, Secchiari F, Gajewski TF, Zwirner NW and Fuertes MB. 2016 NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming Through PD-1/PD-L1 Interactions with Dendritic Cells. J. Immunol. 197:953-961

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F4/80 (BM8.1)

Bracken SJ, Adami AJ, Szczepanek SM, Ehsan M, Natarajan P, Guernsey LA, Shahriari N, Rafti E, Matson AP, Schramm CM and Thrall RS. 2015. Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation. Int Arch Allergy Immunol. 166(4): 243-258.

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Singh V, Holla S, Ramachandra SG and Balaji KN. 2015. WNT-Inflammasome Signaling Mediates NOD2-Induced Development of Acute Arthritis in Mice. J. Immunol. 194(7): 3351-3360.

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Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ and Saleh M. 2015. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. doi: 10.4049 jimmunol.1501529

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinox T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, and Fife BT. 2016. Efficient Generation of Monoclonal Antibodies Against Peptide in the Context of MHCII Using Magnetic Enrichment. Nature Communications. doi:10.1038/ncomms11804

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Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Derderian SC, Schwabe RF, Corvera CU, Grimm D and Willenbring H. 2016. In vivo reprogramming of myofibroblasts into hepatocytes as a therapeutic strategy for liver fibrosis. Cell Stem Cell. 18(6):809-16.

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Daniels MJK, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB and Brough D. 2016. Fenamate NSAIDs Inhibit the NLRP3 Inflammasome and Protect Against Alzheimer's Disease in Rodent Models. Nat. Commun. doi:10.1038/ncomms12504

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Boro M, Singh V and Balaji N. 2016. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci. Rep. doi:10.1038/srep37695

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IFN-g (XMG1.2)

Rydyznski C, Daniels KA, Karmele EP, Brooks TR, Mahl SE, Moran MT, Li C, Sutiwisesak R, Welsh RM and Waggoner SN. 2015. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nat Commun. doi: 10.1038/ncomms7375.

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Zellweger RM, Tang WW, Eddy WE, King K, Sanchez MC and Shresta S. 2015. CD8+ T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice. J Virol. 89(12): 6494-6505.

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Gao Y, Min K, Zhang Y, Su J, Greenwood M and Gronert K. 2015. Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. J Immunol. Doi: 10.4049 jimmunol.1500610.

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Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB and Katsikis PD. 2016. Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice. J Immunol. doi: 10.4049/jimmunol.1502126.

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Khan TN, Mooster JL, Kilgore AM, Osborn JF, and Nolz JC. 2016. Local Antigen in Nonlymphoid Tissue Promotes Resident Memory CD8+ T Cell Formation During Viral Infection. The Journal of Experimental Medicine. doi: 10.1084/jem.20151855

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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IL-2 (JES6-5H4)

Brooks A, Jonkman J, Bookmyer Z and Bruns HA. 2014. Lonicera japonica alters antigen-stimulated T cell functions. Int J Herbal Med. 2(1): 13-20.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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IL-4 (11B11)

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Produhomme T, Duong B, Whang MI, Advincula R, Agelidis A, et al. 2015. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 16(6): 618-627.

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Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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Ly-6G (RB6-8C5)

Hirao H, Uchida Y, Kadono K, Tanaka H, Niki T, Yamauchi A, Hata K, Watanabe T, Terajima H and Uemoto S. 2015. The protective function of galectin-9 in liver ischemia and reperfusion injury in mice. Liver Transpl. doi: 10.1002/lt.24159.

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Bapat SP, Nyoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM and Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 528: 137-141.

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Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E and Kimura T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:18217 doi:10.1038/srep18217.

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

» View on PubMed


Ly-6G (1A8)

Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH and Edelson BT. IL-1 induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 213(2): 251-271.

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Vogel CF, Chang WL, Kado S, McColloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F and Gershwin ME. 2016. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. DOI:10.1289/ehp.1510194.

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Sato T, Kishimoto Y, Asakawa S, Mizuno N, Hiratsuka M and Hirasawa N. 2016. Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology. Volumes 363–364, 1 July 2016, Pages 37–45

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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A and Wong HR. 2016. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. doi: 10.1177/1753425916677073

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Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M and Shibuya A. 2016. Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Int. Immunol. doi: 10.1093/intimm/dxw046

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Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Skon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Kotohara K, Gukovskaya AS, Gukovsky I, Yamamura K, Baba H and Ohmuraya M. 2016. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci. Rep. doi:10.1038/srep37200

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Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. 2016. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J. Clin. Invest. doi:10.1172/JCI88647

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Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM and DeFranco AL. 2016. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLOS one. doi:10.1371/journal.pone.0167693

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NK1.1 (PK136)

O'Sullivan TE, Johnson LR, Kang HH, Sun JC. 2015. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 43: 331-342.

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TCR-beta (H57-597)

Levine AG, Arvey A, Jin W and Rudensky AY. 2014. Continuous requirement for the TCR in regulatory T cell function. Nature Immunol. 15(11): 1070-1078.

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Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T and Watanabe A. 2015. SATB1 Plays a Critical Role in Establishment of Immune Tolerance. J Immunol. doi: 10.4049 ​jimmunol.1501429.

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Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekara G, Schwartz ME et al. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. doi: 10.1038/ni.3290.

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TER-119 (TER-119)

Kudo F, Ikutani M, Seki Y, Otsubo T, Kawamura YI, Dohi T, Oshima K, Hattori M, Nakae S, Takatsu K and Takaki S. 2015. Interferon-γ Constrains Cytokine Production of Group 2 Innate Lymphoid Cells. Immunology. doi: 10.1111/imm.12537.

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KLRG1 (2F1)

Watson AM, Matthew Lam LK, Klimstra WB and Ryman KD. 2016. The 17D-204 Vaccine Strain-Induced Protection Against Virulent Yellow Fever Virus is Mediated by Humoral Immunity and CD4+ But Not CD8+ T Cells. PLoS Pathog. doi:10.1371/journal.ppat.1005786

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MHC Class II (I A/I-E) (M5/114.15.2)

Tiner BL, Sha J, Cong Y, Kirtley ML, Andersson JA and Chopra AK. 2016. Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague. npj Vaccines. doi:10.1038/npjvaccines.2016.20

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Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J and Khader SA. 2016. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat. Commun. doi:10.1038/ncomms13894

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FoxP3 (3G3)

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K and Yasutomo K. 2016. Survival of mature T cells depends on signaling through HOIP. Sci Rep. doi:10.1038/srep36135

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Clones not Specified

O'Donnell H, Pham OH, Li L, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ and McSorley SJ. 2014 Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells. Immunity. 40(2): 213-224.

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Nanton MR, Lee SJ, Atif SM, Nuccio SP, Taylor JJ, Baumler AJ, Way SS and McSorley SJ. 2014. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. Eur J Immunol. 45(2): 428-441.

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Burger ML, Leung KK, Bennett, MJ and Winoto A. 2014. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. eLife 2014;10.7554/eLife.03468.

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Hsu FC, Shapiro MJ, Chen MW, McWilliams DC, Seaburg LM, Tangen SN and Shapiro VS. 2014. Immature Recent Thymic Emigrants Are Eliminated by Complement. J Immunol. 193(12): 6005-6015.

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Nabekura T and Lanier LL. 2014. Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. J Exp Med. 211(12): 2455-2465.

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Cozza EM, Cooper TK, Budgeon LR, Christensen ND and Schell TD. 2014. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. Cancer Immunol Immunother. 64(3): 324-336.

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Liu Z, Zhou H, Wang W, Tan W, Fu YX and Zhu M. 2014. A novel method for synthetic vaccine construction based on protein assembly. Sci Rep. 4: 7266.

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Han D, Walsh MC, Kim KS, Hong SW, Lee J, Yi J, Rivas G, Surh CD and Choi Y. 2015. Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine. PLoS ONE 10(2): e0118795.

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Hemmers S and Rudensky AY. 2015. The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. Cell Rep. 11(9): 1339-1349.

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Doe HT, Kumura D, Miyakoda M, Kimura K, Akbari M and Yui K. 2015. Expression of PD-1/LAG-3 and cytokine production by CD4+ T cells during infection with Plasmodium parasites. Microbiol Immunol. DOI: 10.1111/1348-0421.12354.

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Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T and Hayakawa Y. 2015. Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. Cancer Sci. 106(7): 867-874.

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Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD and Pierce SK. 2015. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc Natl Acad Sci USA. 112(42): 13075-13080.

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Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, Babu S, Kornfeld H and Vankayalapati R. 2016. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection. PloS one. doi.org/10.1371/journal.ppat.1005972

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Caruso G, Distefano DA, Parlascino P, Fresta CG, Lazzarino G, Lunte SM and Nicoletti VG. 20136. Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions. Mol. Cell. Biochem. doi:10.1007/s11010-016-2864-1

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