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APC-Cyanine7 Anti-Human CD45RO (UCHL1)

Sizes available: 25 tests, 100 tests

Applications: FC
SKU: 25-0457
APC-Cyanine7 Anti-Human CD45RO (UCHL1) is available for purchase in increments of 1
Product Name Price Qty
APC-Cyanine7 Anti-Human CD45RO (UCHL1) ..... Cat.No. 25-0457-T025 ..... Size 25 tests
$119.00
APC-Cyanine7 Anti-Human CD45RO (UCHL1) ..... Cat.No. 25-0457-T100 ..... Size 100 tests
$285.00

Description

Details

The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.

The UCHL1 antibody is widely used as a marker for human CD45RO expression on thymocytes, activated memory T cells, monocytes, macrophages and granulocytes. The antibody is reported to be cross-reactive for Chimpanzee CD45RO.

Additional Info

Additional Info

Name APC-Cyanine7 Anti-Human CD45RO (UCHL1)
Cat. No. 25-0457
Technical Data Sheet Download TDS
Alternative Names No
Gene ID 5788
Clone UCHL1
Isotype Mouse IgG2a, kappa
Reactivity Human
Cross Reactivity Chimpanzee
Format APC-Cyanine7
Applications Flow Cytometry
Citations*

Imanguli MM, Swaim WD, League SC, Gress RE, Pavletic SZ, and Hakim FT. 2009. Blood. 113: 3620-3630. (Immunohistochemistry - paraffin embedded tissue)

Di Carlo E, D’Antuono T, Pompa P, Giuliani R, Rosini S, Stuppia L, Musiani P, and Sorrentino C. 2009. Clin. Cancer Res. 15: 2979-2987. (Immunohistochemistry - paraffin embedded tissue)

Kap YS, van Meurs M, van Driel N, Koopman G, Melief M-J, Brok HPM, Laman JD, and ‘t Hart BA. 2009. J.Histochemistry & Cytochemistry. 57: 1159-1167. (Immunohistochemistry - Chimpanzee frozen tissue)

Bonzheim I, Geissinger E, Tinguely M, Roth S, Grieb T, Reimer P, Wilhelm M, Rosenwald A, Muller-Hermelink HK, and Rudiger T. 2008. Am. J. Clin. Pathol. 130: 613-619. (Immunofluorescence microscopy – frozen tissue)

Kim M-H, Suh H-S, Si Q, Terman BE, and Lee SC. 2006. J. Virol. 80: 62-72. (Western Blot)

Cappione AJ, Pugh-Bernard AE, Anolik JH, and Sanz I. 2004. J. Immunol. 172: 4298-4307. (Immunoprecipitation)

Gougeon ML, Lecoeur H, Boudet F, Ledru E. Marzabal S, Boullier S, Roue R, Nagata S, and Heeney J. 1997. J. Immunol. 158: 2964-2976. (Flow cytometry – Chimpanzee)

Kulas DT, Freund GG, and Mooney RA. 1996. J. Biol. Chem. 271: 755-760. (Immunoprecipitation, Western Blot)

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.