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PE-Cyanine7 Anti-Human CD19 (SJ25C1)

Sizes available: 25 tests, 100 tests, 500 tests

Applications: FC
SKU: 60-0198
PE-Cyanine7 Anti-Human CD19 (SJ25C1) is available for purchase in increments of 1
Product Name Price Qty
PE-Cyanine7 Anti-Human CD19 (SJ25C1) ..... Cat.No. 60-0198-T025 ..... Size 25 tests
$115.00
PE-Cyanine7 Anti-Human CD19 (SJ25C1) ..... Cat.No. 60-0198-T100 ..... Size 100 tests
$265.00
PE-Cyanine7 Anti-Human CD19 (SJ25C1) ..... Cat.No. 60-0198-T500 ..... Size 500 tests
$1,193.00

Description

Details

The SJ25C1 antibody reacts with human CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 (CR2), CD81 (TAPA-1) and CD225 (Leu13), in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. Upon activation and tyrosine phosphorylation, the CD19 molecule can provide an anchor for cytoplasmic signaling proteins such as GRB2, SOS or PLCG2. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.

The SJ25C1 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.

Additional Info

Additional Info

Name PE-Cyanine7 Anti-Human CD19 (SJ25C1)
Cat. No. 60-0198
Technical Data Sheet Download TDS
Alternative Names Leu-12, B4
Gene ID 930
Clone SJ25C1
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity No
Format PE-Cyanine7
Applications Flow Cytometry
Citations*

Piatosa B, Birbach M, Siewiera K, Ussowicz M, Kalwak K, Drabko K, Rekawek A, Tkaczyk K, Kurowski PN. 2013. Cytometry Part B. 84B: 179–186. (Flow Cytometry)

Sekiguchi DR, Smith SB, Sutter JA, Goodman NG, Propert K, Louzoun Y, Rogers W, Luning Prak ET. 2011. Cytometry Part B. 80B: 291–299. (Flow Cytometry)

Dörken B, Möller P, Pezzutto A, Schwartz-Albiez R, Moldenhauer G. B-cell antigens: CD19. In: Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:34-36. (Flow Cytometry)

Karahan GE, Eikmans M, Anholts JDH, Class FHJ and Heidt S. 2014. Clin Exp Immunol. 177(1): 333-340. (Flow Cytometry)

Bansal RR, Mackay CR, Moser B and Ebert M. 2012. Eur J Immunol. 42(1): 110-119. (Flow Cytometry)

Jourdan M, Caraux A, Caron G, Robert N, Fiol G, Rème T, Bolloré K, Vendrell JP, Le Gallou S, Mourcin F, De Vos J, Kassambara A, Duperray C, Hose D, Fest T, Tarte K and Klein B. 2011. J Immunol. 187(8): 3931-3941. (Flow Cytometry)

Goval J-J, Greimers R, Boniver J and de Leval L. 2006. J Histochem Cytochem. 54(1): 75-84. (Immunofluorescence – frozen tissue)

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.