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PE-Cyanine5 Anti-Human/Mouse CD44 (IM7)

Sizes available: 25 µg, 100 µg

Applications: FC
SKU: 55-0441
Product Name Price Qty
PE-Cyanine5 Anti-Human/Mouse CD44 (IM7) ..... Cat.No. 55-0441-U025 ..... Size 25 µg
$47.00
PE-Cyanine5 Anti-Human/Mouse CD44 (IM7) ..... Cat.No. 55-0441-U100 ..... Size 100 µg
$101.00

Description

Details

The IM7 antibody recognizes CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organization, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or “standard” form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion.

The IM7 antibody may be used for detection of all isoforms of CD44, as it recognizes constant epitopes near the extracellular proximal domain. (Xu et al, 2002, J. Leukoc. Biol. 72:1133-1141). It has been reported to be cross-reactive with many non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus, Horse, Cow, Pig, Dog and Cat CD44.

Additional Info

Additional Info

Name PE-Cyanine5 Anti-Human/Mouse CD44 (IM7)
Cat. No. 55-0441
Technical Data Sheet Download TDS
Alternative Names Pgp-1, MDU3, Hermes, Hyaluronate receptor
Gene ID 12505
Clone IM7
Isotype Rat IgG2b, kappa
Reactivity Human, Mouse
Cross Reactivity Baboon, Canine, Chimpanzee, Cynomolgus, Equine, Feline, Rhesus, Swine
Format PE-Cyanine5
Applications Flow Cytometry
Citations*

Chandler HL, Haeussler DJ, Gemensky-Metzler AJ, Wilkie DA, and Lutz EA. 2012. Invest. Ophthalmol. Vis. Sci. 53:1835-1845. (in vitro blocking, canine)

Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry).

Ruffell B, Poon GFT, Lee SSM, Brown KL, Tjew S-L, Cooper J, and Johnson P. 2011. J. Biol. Chem. 286:19179-19190. (Immunoprecipitation)

Miyake Y, Matsumoto H, Yokoo M, Miyazawa K et al. 2006. Biol. Reprod. 74: 501-510. (Immunohistochemistry – frozen tissue, swine)

Veir JK, Lappin MR, and Dow SW. 2006. Journal of Feline Medicine and Surgery. 8:400-411. (Flow cytometry – feline)

Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, and Frank MH. 2005. Cancer Res. 65:4320-4333. (Immunohistochemistry – frozen tissue)

Fischer A, Schumacher N, Maier M, Sendtner M, and Gessler M. 2004. Genes & Dev. 18:901-911. (Immunohistochemistry – paraffin embedded tissue)

Xu H, Manivannan A, Liversidge J, Sharp PF, Forrester JV, and Crane IJ. 2002. J. Leukoc. Biol. 72:1133-1141. (in vivo functional assays, induction of apoptosis)

Si-Tahar M, Sitaraman S, Shibahara T, and Madara JL. 2001. Am. J. Physiol. Cell Physiol. 280:C423-C432. (in vitro functional assays, Western Blot)

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.