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APC Anti-Human CD49d (Integrin alpha 4) (9F10)

Sizes available: 25 tests, 100 tests

Applications: FC
SKU: 20-0499
APC Anti-Human CD49d (Integrin alpha 4) (9F10) is available for purchase in increments of 1
Product Name Price Qty
APC Anti-Human CD49d (Integrin alpha 4) (9F10) ..... Cat.No. 20-0499-T025 ..... Size 25 tests
$109.00
APC Anti-Human CD49d (Integrin alpha 4) (9F10) ..... Cat.No. 20-0499-T100 ..... Size 100 tests
$249.00

Description

Details

The 9F10 monoclonal antibody reacts with human CD49d, a 150kD integral membrane protein that is also known as integrin alpha4 (ITGA4). Together with integrin beta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin beta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells as well as extracellular matrix.

Additional Info

Additional Info

Name APC Anti-Human CD49d (Integrin alpha 4) (9F10)
Cat. No. 20-0499
Technical Data Sheet Download TDS
Alternative Names VLA-4 α chain, α4 integrin, Integrin α4 chain, ITGA4
Gene ID No
Clone 9F10
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity No
Format APC
Application Flow Cytometry
Citations*

Hemler ME, Huang C, Takada Y, Schwarz L, Strominger JL, Clabby ML. 1987. J Biol Chem. 262(24):11478-11485.

Hemler ME. 1990. Annu Rev Immunol. 8:365-400.

Berlin C, Berg EL, Briskin MJ, et al. 1993. Cell. 74(1):185-195.

Nevers T, Salvador AM, Velazquez F, Ngwenyama N, Carrillo-Salinas FJ, Aronovitz M, Blanton RM, Alcaide P. 2017. J Exp Med. Nov 6;214(11):3311-3329.

Savino W, Pinto-Mariz F, Mouly V. 2018. Methods Mol Biol. 1687:219-227.

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Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHCF = Immunohistochemistry, Frozen Tissue; IHCP = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.