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In Vivo Ready™ Anti-Mouse CD279 (PD-1) (J43.1)

Sizes available: 100 µg

Applications: FC, FA, IHCF, IP
SKU: 40-9985
In Vivo Ready™ Anti-Mouse CD279 (PD-1) (J43.1) is available for purchase in increments of 1
Product Name Price Qty
In Vivo Ready™ Anti-Mouse CD279 (PD-1) (J43.1) ..... Cat.No. 40-9985-U100 ..... Size 100 µg
$94.00

Description

Details

The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with “B7” ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo. Please choose the appropriate format for each application.

Additional Info

Additional Info

Name In Vivo Ready™ Anti-Mouse CD279 (PD-1) (J43.1)
Cat. No. 40-9985
Technical Data Sheet Download TDS
Alternative Names PDCD1, PD1, SLEB2
Gene ID 18566
Clone J43.1
Isotype Armenian Hamster IgG
Reactivity Mouse
Cross Reactivity No
Format In Vivo Ready™
Applications Flow Cytometry, Functional Assays, IHC, IP
Citations*

Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L, and Fallon PG. 2011. J. Immunol. 186:5648-5655. (in vivo blocking)

Rivas MN, Weatherly K, Hazzan M, Vokaer B, Dremier S, Gaudray F, Goldman M, Salmon I, and Braun MY. 2009. 183:4284-4291. (in vitro blocking)

Koehn BH, Ford ML, Ferrer IR, Borom K, Gangappa S, Kirk AD, and Larsen CP. 2008. J. Immunol. 181:5313-5322. (in vivo blocking)

Brooks DG, Ha S-J, Elsaesser H, Sharpe AH, Freeman GJ, and Oldstone MBA. 2008. Proc. Natl. Acad. Sci. 105:20428-20433. (Flow cytometry)

Ansari MJI, Salama AD, Chitnis T, Smith RN, Yagita H, Akiba H, Yamazaki T, Azuma M, Isai H, Khoury SJ, Auchincloss H, and Sayegh MH. 2003. J. Exp. Med. 198:63-71. (Immunohistochemistry – frozen tissue, in vivo blocking)

Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubat T, Yagita H, and Honjo T. 1996. Int. Immunol. 8:765-772. (Immunoprecipitation)

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.