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FITC Anti-Human CD11c (3.9)

Sizes available: 25 tests, 100 tests

Applications: FC
SKU: 35-0116
FITC Anti-Human CD11c (3.9) is available for purchase in increments of 1
Product Name Price Qty
FITC Anti-Human CD11c (3.9) ..... Cat.No. 35-0116-T025 ..... Size 25 tests
$51.00
FITC Anti-Human CD11c (3.9) ..... Cat.No. 35-0116-T100 ..... Size 100 tests
$77.00

Description

Details

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

Additional Info

Additional Info

Name FITC Anti-Human CD11c (3.9)
Cat. No. 35-0116
Technical Data Sheet Download TDS
Alternative Names No
Gene ID No
Clone 3.9
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Baboon, Chimpanzee, Cynomolgus, Rhesus
Format FITC
Applications Flow Cytometry
Citations*

Robinson BA, Estep RD, Messaoudi I, Rogers KS, and Wong SW. J. Virol. 2012. 86:2197-2211. (Flow cytometry – rhesus macaque)

Campillo-Gimenez L, Laforge M, Fay M, Brussel A, et. al. 2010. J. Virol. 84(4):1838-1846. (Flow cytometry – African green monkey, rhesus macaque)

Sadhu C, Hendrickson L, Dick KO, Potter TG, and Staunton DE. 2008. J. Immunoassay Immunochem. 29(1):42-57. (in vitro blocking)

Arndt S, Melle C, Mondal K, Klein G, von Eggeling F, and Bosserhoff A-K. 2007. J. Leukoc. Biol. 82:1466-1472. (Immunoprecipitation)

McGreal EP, Ikewaki N, Akatsu H, Morgan BP, and Gasque P. 2002. 168:5222-5232. (Immunofluorescence microscopy – frozen tissue)

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.