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Description
Details
The MR1 antibody is specific for mouse CD154, a 39 kD glycoprotein that is primarily expressed on activated T cells. CD154 (CD40 ligand, gp39) binds to CD40 expressed on antigen presenting cells and mediates important costimulatory functions between these cells. Signals generated via cognate interactions between CD154-CD40 on activated T and B cells are required for T-dependent B cell responses. The MR1 antibody is reported to block interaction of CD154 with CD40.
Additional Info
Additional Info
| Name | Biotin Anti-Mouse CD154 (MR1) |
|---|---|
| Cat. No. | 30-1541 |
| Technical Data Sheet | Download TDS |
| Alternative Names | CD40L, TRAP, Ly-62, TNFSF5 |
| Gene ID | 21947 |
| Clone | MR1 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Cross Reactivity | No |
| Format | Biotin |
| Application | Flow Cytometry |
| Citations* | Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. 1992. Proc Natl Acad Sci U S A. 89(14):6550-6554. Foy TM, Laman JD, Ledbetter JA, Aruffo A, Claassen E, Noelle RJ. 1994. J Exp Med. 180(1):157-163. Laman JD, Claassen E, Noelle RJ. 1996. Crit Rev Immunol. 16(1):59-108. Grewal IS, Flavell RA. 1998. Annu Rev Immunol. 16:111-35. |