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APC Anti-Mouse CD357 (GITR) (DTA-1)

Sizes available: 25 µg, 100 µg

Applications: FC
SKU: 20-5874
Product Name Price Qty
APC Anti-Mouse CD357 (AITR / GITR) (DTA-1) ..... Cat.No. 20-5874-U025 ..... Size 25 µg
$78.00
APC Anti-Mouse CD357 (AITR / GITR) (DTA-1) ..... Cat.No. 20-5874-U100 ..... Size 100 µg
$185.00

Description

Details

The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays (use format appropriate for functional assays).

Additional Info

Additional Info

Name APC Anti-Mouse CD357 (GITR) (DTA-1)
Cat. No. 20-5874
Technical Data Sheet Download TDS
Alternative Names TNFRSF18
Gene ID 21936
Clone DTA-1
Isotype Rat IgG2b
Reactivity Mouse
Cross Reactivity
Format APC
Applications Flow Cytometry
Citations*

Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry).

Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, and Gelfand EW. 2012. J. Biol. Chem. 287: 17100-17108. (in vitro activation)

Van der Werf N, Redpath SA, Phythian-Adams AT, Azuma M, Allen JE, Maizels RM, Macdonald AS, and Taylor MD. 2011. J. Immunol. 187: 1411-1420. (in vivo activation)

Molloy MJ, Zhang W, and Usherwood EJ. 2011. J. Immunol. 186: 6218-6226. (in vivo activation) ll

Yokoyama T, Matsuda S, Takae Y, Wada N, Nishikawa T, Amagai M, and Koyasu S. 2011. Int. Immunol. 23: 365-373. (Treg depletion – magnetic beads)

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Applications Guide:
FC = Flow Cytometry, FA = Functional Assays, ICC = Immunocytochemistry, IHC = Immunohistochemistry, IHCF = Immunohistochemistry, Frozen Tissue, IHCP = Immunohistochemistry, Paraffin-embedded Tissue, IF = Immunofluorescence Microscopy, IP = Immunoprecipitation, WB = Western Blot, EM = electron microscopy


*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.