The RPA-2.10 antibody reacts with human CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD58 in the human and is expressed on the cell surface of 80-90% of human peripheral blood lymphocytes, a subset of NK cells, and all mature T cells. CD2 mediates lymphocyte adhesion and is involved in T cell activation.
RPA-2.10 is reported to block mixed lymphocyte reaction. Please choose the appropriate format for each application.
|Name||APC Anti-Human CD2 (RPA-2.10)|
|Technical Data Sheet||Download TDS|
|Alternative Names||LFA-2, T11, Sheep Red Blood Cell Receptor (SRBC-R), Ly-37|
|Isotype||Mouse IgG1, kappa|
|Cross Reactivity||Baboon, Chimpanzee, Cynomolgus, Capuchin Monkey, Rhesus, Pigtailed Macaque, Swine|
Knapp W, Dorken B, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
Aversa GG, Bishop GA, Suranyi MG and Hall BM. 1987. Transplant Proc. 19: 277-278.
Hahn WC, Burakoff SJ, Bierer BE. 1993. J Immunol. 150(7):2607-2619.
Xu H, Elster EA, Blair PJ, Burkly LC, Tadaki DK, Harlan DM and Kirk AD. 2003. Am J Transplant. 3: 1350-1354. (Immunohistochemistry – frozen tissue)
Kim EO, Kim TJ, Kim N, Kim ST, Kumar V and Lee KM. 2010. J Biol Chem. 285: 41755-41764. (in vitro blocking)
Schernthaner GH, Jordan JH, Ghannadan M, Agis H, Bevec D, Nunez R, Escribano L, Majdic O, Willheim M, Worda C, Printz D, Fritsch G, Lechner K and Valent P. 2001. Blood. 98(13): 3784-3792. (Flow Cytometry)
Herodin F, Thullier P, Garin D and Drouet M. 2005. Eur Cytokine Netw. 16(2): 104-116. (Flow Cytometry – Baboon, Chimpanzee, Cynomolgus, Rhesus)